Cobalt Protoporphyrin Improves Heart Function by Attenuating Cardiac Beta-oxidation and Restoring Redox Balance in an Animal Model of Experimental Diabetes

Cobalt Protoporphyrin Improves Heart Function by Attenuating Cardiac Beta-oxidation and Restoring Redox Balance in an Animal Model of Experimental Diabetes

Myocardial dysfunction and coronary macro/microvascular alterations are the hallmarks of diabetic cardiomyopathy and are ascribed to increased oxidative stress and altered nitric oxide synthase (NOS) activity. We hypothesize that pretreatment by cobalt-protoporphyrin IX (CoPP) ameliorates both myoca...

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Bibliographic Details
Main Authors: Jian eCao, Cecilia eVecoli, Danilo eNeglia, Barbara eTavazzi, Giuseppe eLazzarino, Michela eNovelli, Pellegrino eMasiello, Yu-tang eWang, Nazareno ePaolocci, Nitin ePuri, Antonio eL'Abbate, Nader G. Abraham
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Physiology
Subjects:
Nitric Oxide
Oxidative Stress
signalling
cardiac disease
diabetes
cardiac contractility
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00160/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00160/full

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