In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats

In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats

Polyglutamine diseases, including Huntington’s disease and a number of spinocerebellar ataxias, are caused by expanded CAG repeats that are located in translated sequences of individual, functionally-unrelated genes. Only mutant proteins containing polyglutamine expansions have long been thought to...

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Bibliographic Details
Main Authors: Grzegorz Figura, Edyta Koscianska, Wlodzimierz J. Krzyzosiak
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
SLIP
trinucleotide repeats
in vitro expansion
repeats in vitro cloning
polyglutamine diseases
plasmid constructs
Online Access:http://www.mdpi.com/1422-0067/16/8/18741

Internet

http://www.mdpi.com/1422-0067/16/8/18741

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