Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans.

Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans.

Synthesis of ribosomal RNA by RNA polymerase I (RNA pol I) is an elemental biological process and is key for cellular homeostasis. In a forward genetic screen in C. elegans designed to identify DNA damage-response factors, we isolated a point mutation of RNA pol I, rpoa-2(op259), that leads to alter...

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Bibliographic Details
Main Authors: Ralf Eberhard, Lilli Stergiou, E Randal Hofmann, Jen Hofmann, Simon Haenni, Youjin Teo, André Furger, Michael O Hengartner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3836707?pdf=render

Internet

http://europepmc.org/articles/PMC3836707?pdf=render

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