Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices

Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices

Dopaminergic (DA) midbrain neurons within the substantia nigra (SN) display an autonomous pacemaker activity that is crucial for dopamine release and voluntary movement control. Their progressive degeneration is a hallmark of Parkinson's disease. Their metabolically demanding activity-mode affe...

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Bibliographic Details
Main Authors: Nadja Mannal, Katharina Kleiner, Michael Fauler, Antonios Dougalis, Christina Poetschke, Birgit Liss
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
glucose-excited GE-neurons
dopamine excited neurons
dopamine inhibited neurons
dopamine-autoreceptor
neuronal calcium sensor NCS-1
GIRK channel
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2021.635050/full

Internet

https://www.frontiersin.org/articles/10.3389/fnsyn.2021.635050/full

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