NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization

NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization

NOSH-NBP, a novel nitric oxide (NO) and hydrogen sulfide (H2S)-releasing hybrid, protects brain from ischemic stroke. This study mainly aimed to investigate the therapeutic effect of NOSH-NBP on ischemic stroke and the underlying mechanisms. In vivo, transient middle cerebral artery occlusion (tMCAO...

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Bibliographic Details
Main Authors: Jing Ji, Pengjun Xiang, Tingting Li, Li Lan, Xiaole Xu, Guo Lu, Hui Ji, Yihua Zhang, Yunman Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
NOSH-NBP
ischemic stroke
neurovascular unit
microglial/macrophage polarization
TLR4/MyD88/NF-κB pathway
NLRP3 inflammasome
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00154/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00154/full

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