Pain Input After Spinal Cord Injury (SCI) Undermines Long-Term Recovery and Engages Signal Pathways That Promote Cell Death

Pain Input After Spinal Cord Injury (SCI) Undermines Long-Term Recovery and Engages Signal Pathways That Promote Cell Death

Pain (nociceptive) input caudal to a spinal contusion injury increases tissue loss and impairs long-term recovery. It was hypothesized that noxious stimulation has this effect because it engages unmyelinated pain (C) fibers that produce a state of over-excitation in central pathways. The present art...

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Bibliographic Details
Main Authors: Joel D. Turtle, Misty M. Strain, Joshua A. Reynolds, Yung-Jen Huang, Kuan H. Lee, Melissa K. Henwood, Sandra M. Garraway, James W. Grau
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Systems Neuroscience
Subjects:
spinal cord injury
pain
capsaicin
cell death
apoptosis
pyroptosis
Online Access:https://www.frontiersin.org/article/10.3389/fnsys.2018.00027/full

Internet

https://www.frontiersin.org/article/10.3389/fnsys.2018.00027/full

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