Correlative Monitoring of Immune Activation and Tissue Damage in Malignant Melanoma—An Algorithm for Identification of Tolerance Breakage During Immune Checkpoint Inhibitor Therapy of Cancer

Correlative Monitoring of Immune Activation and Tissue Damage in Malignant Melanoma—An Algorithm for Identification of Tolerance Breakage During Immune Checkpoint Inhibitor Therapy of Cancer

We describe an innovative approach for identification of tolerance breakage during immune checkpoint inhibitor therapy in malignant melanoma. Checkpoint inhibitor therapy enhances the immunologic clearance of cancer by suppressing pathways which induce immune suppression and tolerance. We posit that...

Full description

Bibliographic Details
Main Authors: Renate U. Wahl, Marike Leijs, Arturo Araujo, Albert Rübben
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
treatment monitoring
tolerance breakage
checkpoint inhibitor therapy
temporal correlation
malignant melanoma
interleukin 6
s100b
eosinophils
macrophages
irae
Online Access:https://www.mdpi.com/1422-0067/21/6/2020

Internet

https://www.mdpi.com/1422-0067/21/6/2020

Similar Items