Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice

Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice

The analogous β-carboline alkaloids, harmaline (HAL) and harmine (HAR), possess a variety of biological properties, including acetylcholinesterase (AChE) inhibitory activity, antioxidant, anti-inflammatory, and many others, and have great potential for treating Alzheimer’s disease (AD). However, stu...

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Bibliographic Details
Main Authors: Shu-Ping Li, Yu-Wen Wang, Sheng-Lan Qi, Yun-Peng Zhang, Gang Deng, Wen-Zheng Ding, Chao Ma, Qi-Yan Lin, Hui-Da Guan, Wei Liu, Xue-Mei Cheng, Chang-Hong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
harmaline
harmine
scopolamine
systemic injections
memory deficits
cholinergic function
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00346/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00346/full

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