Panax Notoginseng Saponins Protect Cardiac Myocytes Against Endoplasmic Reticulum Stress and Associated Apoptosis Through Mediation of Intracellular Calcium Homeostasis

Panax Notoginseng Saponins Protect Cardiac Myocytes Against Endoplasmic Reticulum Stress and Associated Apoptosis Through Mediation of Intracellular Calcium Homeostasis

Endoplasmic reticulum (ER) stress has been demonstrated to play important roles in the pathogenesis of various cardiovascular diseases. The ER stress pathway is therefore a promising therapeutic target in cardiovascular disease. Although Panax notoginseng saponins (PNS) are one of the patent medicin...

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Bibliographic Details
Main Authors: Jun Chen, Rui Xue, Li Li, Li Li Xiao, Jiahong Shangguan, Wenjing Zhang, Xueyang Bai, Gangqiong Liu, Ling Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
Panax notoginseng saponins
endoplasmic reticulum stress
apoptosis
intracellular calcium homeostasis
ryanodine receptor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01013/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01013/full

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