Distinct Effects of Stereotactically Injected Human Cerebrospinal Fluid Containing Glutamic Acid Decarboxylase Antibodies into the Hippocampus of Rats on the Development of Spontaneous Epileptic Activity

Distinct Effects of Stereotactically Injected Human Cerebrospinal Fluid Containing Glutamic Acid Decarboxylase Antibodies into the Hippocampus of Rats on the Development of Spontaneous Epileptic Activity

<i>Background</i>: The conversion of glutamic acid into &#947;-aminobutyric acid (GABA) is catalyzed by the glutamic acid decarboxylase (GAD). Antibodies against this enzyme have been described in neurological disorders, but the pathophysiological role of these antibodies is still po...

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Bibliographic Details
Main Authors: Bernd Frerker, Marco Rohde, Steffen Müller, Christian G. Bien, Rüdiger Köhling, Timo Kirschstein
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Brain Sciences
Subjects:
glutamic acid decarboxylase
autoimmune limbic encephalitis
nmda and gaba receptor
recurrent epileptiform discharges
human cerebrospinal fluid
hippocampus of rats
field potential recording
Online Access:https://www.mdpi.com/2076-3425/10/2/123

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https://www.mdpi.com/2076-3425/10/2/123

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