Achieving the goal of optimised renin system suppression: preclinical experience with a direct renin inhibitor
Aliskiren is the first orally available direct renin inhibitor and is a highly potent and specific inhibitor of human renin.The high specificity for human renin has resulted in considerable challenges in utilising animal models in preclinical studies. Both marmoset and spontaneously hypertensive rat...
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| Format: | Article |
| Language: | English |
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Hindawi - SAGE Publishing
2006-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | http://jra.sagepub.com/content/7/2_suppl/S12.full.pdf |