Acute Conditioning of Antigen-Expanded CD8<sup>+</sup> T Cells Via the GSK3β-mTORC Axis Differentially Dictates Their Immediate and Distal Responses after Antigen Rechallenge

Acute Conditioning of Antigen-Expanded CD8<sup>+</sup> T Cells Via the GSK3β-mTORC Axis Differentially Dictates Their Immediate and Distal Responses after Antigen Rechallenge

CD8<b><sup>+</sup></b>T cells protect against tumors and intracellular pathogens. The inflammatory cytokines IL-2, IL-15, and IL-7 are necessary for their expansion. However, elevated serum levels of these cytokines are often associated with cancer, poorer prognosis of cancer...

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Bibliographic Details
Main Authors: Pavla Taborska, Dmitry Stakheev, Hana Svobodova, Zuzana Strizova, Jirina Bartunkova, Daniel Smrz
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
CD8<sup>+ </sup>T cells
antigen rechallenge
cytokine starvation
Tim-3
mTOR
GSK-3β
Online Access:https://www.mdpi.com/2072-6694/12/12/3766

Internet

https://www.mdpi.com/2072-6694/12/12/3766

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