Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients

Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients

Abstract Background In chronic lymphocytic leukemia (CLL) disease onset and progression are influenced by the behavior of specific CD4+ T cell subsets, such as T regulatory cells (Tregs). Here, we focused on the phenotypic and functional characterization of Tregs in CLL patients to improve our under...

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Bibliographic Details
Main Authors: Serena De Matteis, Chiara Molinari, Giulia Abbati, Tania Rossi, Roberta Napolitano, Martina Ghetti, Andrea Ghelli Luserna Di Rorà, Gerardo Musuraca, Alessandro Lucchesi, Gian Matteo Rigolin, Antonio Cuneo, Daniele Calistri, Pier Paolo Fattori, Massimiliano Bonafè, Giovanni Martinelli
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Translational Medicine
Subjects:
CLL
Tregs
Plasticity
Effector-like Tregs
Online Access:http://link.springer.com/article/10.1186/s12967-018-1545-0

Internet

http://link.springer.com/article/10.1186/s12967-018-1545-0

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