Antiplatelet effect of catechol is related to inhibition of cyclooxygenase, reactive oxygen species, ERK/p38 signaling and thromboxane A2 production.

Catechol (benzenediol) is present in plant-derived products, such as vegetables, fruits, coffee, tea, wine, areca nut and cigarette smoke. Because platelet dysfunction is a risk factor of cardiovascular diseases, including stroke, atherosclerosis and myocardial infarction, the purpose of this study...

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Main Authors: Mei-Chi Chang, Hsiao-Hua Chang, Tong-Mei Wang, Chiu-Po Chan, Bor-Ru Lin, Sin-Yuet Yeung, Chien-Yang Yeh, Ru-Hsiu Cheng, Jiiang-Huei Jeng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4133398?pdf=render