Spinal Cord Molecular and Cellular Changes Induced by Adenoviral Vector- and Cell-Mediated Triple Gene Therapy after Severe Contusion

Spinal Cord Molecular and Cellular Changes Induced by Adenoviral Vector- and Cell-Mediated Triple Gene Therapy after Severe Contusion

The gene therapy has been successful in treatment of spinal cord injury (SCI) in several animal models, although it still remains unavailable for clinical practice. Surprisingly, regardless the fact that multiple reports showed motor recovery with gene therapy, little is known about molecular and ce...

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Bibliographic Details
Main Authors: Andrei A. Izmailov, Tatyana V. Povysheva, Farid V. Bashirov, Mikhail E. Sokolov, Filip O. Fadeev, Ravil R. Garifulin, Boris S. Naroditsky, Denis Y. Logunov, Ilnur I. Salafutdinov, Yuri A. Chelyshev, Rustem R. Islamov, Igor A. Lavrov
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
spinal cord injury
glial cells
gene therapy
human umbilical cord blood mononuclear cell
vascular endothelial growth factor
glial cell-derived neurotrophic factor
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00813/full

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http://journal.frontiersin.org/article/10.3389/fphar.2017.00813/full

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