Protein Degradation Pathways Regulate the Functions of Helicases in the DNA Damage Response and Maintenance of Genomic Stability

Protein Degradation Pathways Regulate the Functions of Helicases in the DNA Damage Response and Maintenance of Genomic Stability

Degradation of helicases or helicase-like proteins, often mediated by ubiquitin-proteasomal pathways, plays important regulatory roles in cellular mechanisms that respond to DNA damage or replication stress. The Bloom’s syndrome helicase (BLM) provides an example of how helicase degradation pathways...

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Bibliographic Details
Main Authors: Joshua A. Sommers, Avvaru N. Suhasini, Robert M. Brosh
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Biomolecules
Subjects:
helicase
DNA damage response
proteasome
ubiquitin
phosphorylation
acetylation
post-translational modification
Bloom’s syndrome
Fanconi Anemia
Cockayne syndrome
Werner syndrome
Online Access:http://www.mdpi.com/2218-273X/5/2/590

Internet

http://www.mdpi.com/2218-273X/5/2/590

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