Proteome Stability as a Key Factor of Genome Integrity

Proteome Stability as a Key Factor of Genome Integrity

DNA damage is constantly produced by both endogenous and exogenous factors; DNA lesions then trigger the so-called DNA damaged response (DDR). This is a highly synchronized pathway that involves recognition, signaling and repair of the damage. Failure to eliminate DNA lesions is associated with geno...

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Bibliographic Details
Main Authors: Sentiljana Gumeni, Zoi Evangelakou, Vassilis G. Gorgoulis, Ioannis P. Trougakos
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:International Journal of Molecular Sciences
Subjects:
aggregates
autophagy
DNA damage response
genome instability
Nrf2
oxidative stress
proteostasis
proteasome
Online Access:https://www.mdpi.com/1422-0067/18/10/2036

Internet

https://www.mdpi.com/1422-0067/18/10/2036

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