Synthesis and Different Effects of Biotinylated PAMAM G3 Dendrimer Substituted with Nimesulide in Human Normal Fibroblasts and Squamous Carcinoma Cells

Synthesis and Different Effects of Biotinylated PAMAM G3 Dendrimer Substituted with Nimesulide in Human Normal Fibroblasts and Squamous Carcinoma Cells

Squamous cell carcinoma (SCC) remains a main cause of mortality in patients with neck and head cancers, with poor prognosis and increased prevalence despite of available therapies. Recent studies have identified a role of cyclooxygenases, particularly inducible isoform cyclooxygenase-2 (COX-2) and i...

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Bibliographic Details
Main Authors: Łukasz Uram, Aleksandra Filipowicz-Rachwał, Maria Misiorek, Aleksandra Winiarz, Elżbieta Wałajtys-Rode, Stanisław Wołowiec
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
nimesulide
biotinylated PAMAM G3 dendrimer conjugates
normal human fibroblasts and squamous cell carcinoma
cytotoxicity
proliferation
COX-2/PGE<sub>2</sub> axis
Online Access:https://www.mdpi.com/2218-273X/9/9/437

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https://www.mdpi.com/2218-273X/9/9/437

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