MD Simulations on a Well-Built Docking Model Reveal Fine Mechanical Stability and Force-Dependent Dissociation of Mac-1/GPIbα Complex

MD Simulations on a Well-Built Docking Model Reveal Fine Mechanical Stability and Force-Dependent Dissociation of Mac-1/GPIbα Complex

Interaction of leukocyte integrin macrophage-1 antigen (Mac-1) to platelet glycoprotein Ibα (GPIbα) is critical for platelet–leukocyte crosstalk in hemostasis and inflammatory responses to vessel injuries under hemodynamic environments. The mechano-regulation and its molecular basis for binding of M...

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Bibliographic Details
Main Authors: Xiaoyan Jiang, Xiaoxi Sun, Jiangguo Lin, Yingchen Ling, Ying Fang, Jianhua Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
Mac-1
GPIbα
molecular dynamics simulation
structure–function relation
leukocyte–platelet interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.638396/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.638396/full

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