The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions.

The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions.

Resistance to HIV-1 integrase (IN) inhibitor raltegravir (RAL), is encoded by mutations in the IN region of the pol gene. The emergence of the N155H mutation was replaced by a pattern including the Y143R/C/H mutations in three patients with anti-HIV treatment failure. Cloning analysis of the IN gene...

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Bibliographic Details
Main Authors: Sandrine Reigadas, Guerric Anies, Bernard Masquelier, Christina Calmels, Lieven J Stuyver, Vincent Parissi, Herve Fleury, Marie-Line Andreola
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2859942?pdf=render

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http://europepmc.org/articles/PMC2859942?pdf=render

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