Suppression of TRPM2 reduces renal fibrosis and inflammation through blocking TGF-β1-regulated JNK activation

Suppression of TRPM2 reduces renal fibrosis and inflammation through blocking TGF-β1-regulated JNK activation

Chronic kidney disease (CKD) is a major cause of death. Renal fibrosis and inflammation are common pathways contributing to the development of this disease. However, the molecular mechanisms underlying CKD are not fully understood. TRPM2 (Transient receptor potential melastatin-2) was previously ide...

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Bibliographic Details
Main Authors: Ying Wang, Lingwei Chen, Kangyao Wang, Yuanting Da, Min Zhou, Haihong Yan, Dan Zheng, Sen Zhong, Shasha Cai, Huiping Zhu, Yunsheng Li
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Chronic kidney disease
TRPM2
Fibrosis and inflammation
TGF-β1
JNK
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219351790

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http://www.sciencedirect.com/science/article/pii/S0753332219351790

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