Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein

Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein

Many current malaria vaccines target the pre-erythrocytic stage of infection in the liver. However, in malaria-endemic regions, increased blood stage exposure is associated with decreased vaccine efficacy, thereby challenging current vaccine efforts. We hypothesized that pre-erythrocytic humoral imm...

Full description

Bibliographic Details
Main Authors: Gladys J. Keitany, Karen S. Kim, Akshay T. Krishnamurty, Brian D. Hondowicz, William O. Hahn, Nicholas Dambrauskas, D. Noah Sather, Ashley M. Vaughan, Stefan H.I. Kappe, Marion Pepper
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Cell Reports
Subjects:
malaria
plasmodium
memory B cells
attenuated parasites
vaccines
antibodies
humoral immunity
antigen specific B cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716316333

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716316333

Similar Items