Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain

Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain

Multiple system atrophy (MSA) is a progressive neurodegenerative disease clinically characterized by parkinsonism and cerebellar ataxia, and pathologically by oligodendrocyte α-synuclein inclusions. Genetic variants of COQ2 are associated with an increased risk for MSA in certain populations. Also,...

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Bibliographic Details
Main Authors: Jen-Hsiang T. Hsiao, Sivaraman Purushothuman, Poul H. Jensen, Glenda M. Halliday, Woojin Scott Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Neuroscience
Subjects:
multiple system atrophy
parkinsonian disorders
COQ2
COQ7
ATP
coenzyme Q10
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01187/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.01187/full

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