Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells

Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells

Excessive reactive oxygen species (ROS) and apoptosis in nucleus pulposus (NP) cells accelerate the process of intervertebral disc degeneration (IDD). Here, we integrated pathological samples and in vitro and in vivo framework to investigate the impact of phosphorylation of eukaryotic initiation fac...

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Bibliographic Details
Main Authors: Junping Bao, Zhanyang Qian, Lei Liu, Xin Hong, Hui Che, Xiaotao Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
intervertebral disc degeneration
apoptosis
reactive oxygen species
eIF2 alpha
activating transcription factor 4
Indian hedgehog
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.675486/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.675486/full

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