Amyloid-β Peptide Impact on Synaptic Function and Neuroepigenetic Gene Control Reveal New Therapeutic Strategies for Alzheimer’s Disease

Amyloid-β Peptide Impact on Synaptic Function and Neuroepigenetic Gene Control Reveal New Therapeutic Strategies for Alzheimer’s Disease

Amyloid-β (Aβ) peptides can form protease-resistant aggregates within and outside of neurons. Accumulation of these aggregates is a hallmark of Alzheimer’s disease (AD) neuropathology and contributes to devastating cognitive deficits associated with this disorder. The primary etiological factor for...

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Bibliographic Details
Main Authors: Bhanu Chandra Karisetty, Akanksha Bhatnagar, Ellen M. Armour, Mariah Beaver, Haolin Zhang, Felice Elefant
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuroepigenetics
TIP60
synaptic function
therapeutics
amyloid beta
KAT5
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2020.577622/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2020.577622/full

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