Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence.

L-citrulline and L-arginine supplementation has been shown to have several beneficial effects on the cardiovascular system. Nitric oxide (NO) protects against the progression of atherosclerosis and is synthesized by nitric oxide synthase (NOS), which converts L-arginine (L-Arg) into L-citrulline (L-...

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Bibliographic Details
Main Authors: Tomoe Tsuboi, Morihiko Maeda, Toshio Hayashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5802914?pdf=render