The Human Cytomegalovirus Nonstructural Glycoprotein UL148 Reorganizes the Endoplasmic Reticulum

The Human Cytomegalovirus Nonstructural Glycoprotein UL148 Reorganizes the Endoplasmic Reticulum

Perturbations to endoplasmic reticulum (ER) morphology occur during infection with various intracellular pathogens and in certain genetic disorders. We identify that a human cytomegalovirus (HCMV) gene product, UL148, profoundly reorganizes the ER during infection and is sufficient to do so when exp...

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Bibliographic Details
Main Authors: Hongbo Zhang, Clarissa Read, Christopher C. Nguyen, Mohammed N. A. Siddiquey, Chaowei Shang, Cameron M. Hall, Jens von Einem, Jeremy P. Kamil
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mBio
Subjects:
cytomegalovirus
glycoproteins
herpesviruses
organelle structure
secretory pathway
stress adaptation
stress response
unfolded protein response
virus entry
Online Access:https://doi.org/10.1128/mBio.02110-19

Internet

https://doi.org/10.1128/mBio.02110-19

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