Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease

Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease

Abstract Background Identifying effective strategies to prevent memory loss in AD has eluded researchers to date, and likely reflects insufficient understanding of early pathogenic mechanisms directly affecting memory encoding. As synaptic loss best correlates with memory loss in AD, refocusing effo...

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Bibliographic Details
Main Authors: Shreaya Chakroborty, Evan S. Hill, Daniel T. Christian, Rosalind Helfrich, Shannon Riley, Corinne Schneider, Nicolas Kapecki, Sarah Mustaly-Kalimi, Figen A. Seiler, Daniel A. Peterson, Anthony R. West, Barbara M. Vertel, William N. Frost, Grace E. Stutzmann
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Molecular Neurodegeneration
Subjects:
Synaptic
Hippocampus
Short-term plasticity
Synaptic vesicles
Calcium
Ryanodine receptor
Online Access:http://link.springer.com/article/10.1186/s13024-019-0307-7

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http://link.springer.com/article/10.1186/s13024-019-0307-7

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