Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission

Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission

Genetic variants of the fragile X mental retardation syndrome-related protein 1 (FXR1) have been associated to mood regulation, schizophrenia, and bipolar disorders. Nonetheless, genetic association does not indicate a functional link of a given gene to neuronal activity and associated behaviors. In...

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Bibliographic Details
Main Authors: Jivan Khlghatyan, Alesya Evstratova, Simon Chamberland, Aleksandra Marakhovskaia, Arash Bahremand, Katalin Toth, Jean-Martin Beaulieu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
fragile X proteins
GSK-3
mood disorders
CRISPR/Cas9
frontal cortex
AMPAR
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00119/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00119/full

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