Interleukin-1 beta promotes neuronal differentiation through the Wnt5a/RhoA/JNK pathway in cortical neural precursor cells

Interleukin-1 beta promotes neuronal differentiation through the Wnt5a/RhoA/JNK pathway in cortical neural precursor cells

Abstract Pro-inflammatory cytokine interleukin-1 beta (IL-1β) is a key mediator of inflammation and stress in the central nervous system (CNS), and is highly expressed in the developing brain. In this study, we investigated the possible role of IL-1β in neuronal differentiation of cortical neural pr...

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Bibliographic Details
Main Authors: Shin-Young Park, Min-Jeong Kang, Joong-Soo Han
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Molecular Brain
Subjects:
Interleukin-1 beta (IL-1β)
Neuronal differentiation
Wnt5a
RhoA
C-jun N-terminal kinase (JNK)
Online Access:http://link.springer.com/article/10.1186/s13041-018-0383-6

Internet

http://link.springer.com/article/10.1186/s13041-018-0383-6

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