A mechanism underlying the neurotoxicity induced by sodium fluoride and its reversal by epigallocatechin gallate in the rat hippocampus: involvement of NrF2/Keap-1 signaling pathway

A mechanism underlying the neurotoxicity induced by sodium fluoride and its reversal by epigallocatechin gallate in the rat hippocampus: involvement of NrF2/Keap-1 signaling pathway

Abstract Background Fluoride (Fl) exposure engenders neurodegeneration and induces oxidative stress in the brain. Therefore, the mechanism of Fl-induced neurotoxic effects needs to be determined. The aim of this study was to investigate the neuroprotective effects of EGCG (40 mg/kg) on Fl (25 mg/kg/...

Full description

Bibliographic Details
Main Authors: Thangapandiyan Shanmugam, Sharmilabanu Abdulla, Vadivazhagi Yakulasamy, Miltonprabu Selvaraj, Ramesh Mathan
Format: Article
Language:English
Published: SpringerOpen 2018-02-01
Series:Journal of Basic and Applied Zoology
Subjects:
Fluoride
Epigallocatechin gallate
ROS
Nrf2/Keap1
Rat
Hippocampus
Online Access:http://link.springer.com/article/10.1186/s41936-018-0020-z

Internet

http://link.springer.com/article/10.1186/s41936-018-0020-z

Similar Items