Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos.
The methylation of cytosine at CG sites in the mammalian genome is dynamically reprogrammed during gametogenesis and preimplantation development. It was previously shown that oocyte-derived DNMT1 (a maintenance methyltransferase) is essential for maintaining and propagating CG methylation at imprint...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-10-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC5643148?pdf=render |