Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro

Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro

Guanidine alkaloids from sponges Monanchora spp. represent diverse bioactive compounds, however, the mechanisms underlying bioactivity are very poorly understood. Here, we report results of studies on cytotoxic action, the ability to inhibit EGF-induced neoplastic transformation, and the effects on...

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Bibliographic Details
Main Authors: Sergey A. Dyshlovoy, Kseniya M. Tabakmakher, Jessica Hauschild, Regina K. Shchekaleva, Katharina Otte, Alla G. Guzii, Tatyana N. Makarieva, Ekaterina K. Kudryashova, Sergey N. Fedorov, Larisa K. Shubina, Carsten Bokemeyer, Friedemann Honecker, Valentin A. Stonik, Gunhild von Amsberg
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Marine Drugs
Subjects:
guanidine alkaloids
monanchocidin A
Monanchora pulchra
apoptosis
MAPK
AP-1
neoplastic transformation
Online Access:http://www.mdpi.com/1660-3397/14/7/133

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http://www.mdpi.com/1660-3397/14/7/133

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