Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation

Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation

Abstract Background Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known that denervation promotes mitochondrial reactive oxygen species (ROS) pr...

Full description

Bibliographic Details
Main Authors: Chehade Karam, Jianxun Yi, Yajuan Xiao, Kamal Dhakal, Lin Zhang, Xuejun Li, Carlo Manno, Jiejia Xu, Kaitao Li, Heping Cheng, Jianjie Ma, Jingsong Zhou
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Skeletal Muscle
Subjects:
E-C coupling
Calcium imaging
Calcium signaling
Calcium intracellular release
Denervation
Mitochondria
Online Access:http://link.springer.com/article/10.1186/s13395-017-0123-0

Internet

http://link.springer.com/article/10.1186/s13395-017-0123-0

Similar Items