Dynamic ligand modulation of EPO receptor pools, and dysregulation by polycythemia-associated EPOR alleles.

Dynamic ligand modulation of EPO receptor pools, and dysregulation by polycythemia-associated EPOR alleles.

Erythropoietin (EPO) and its cell surface receptor (EPOR) are essential for erythropoiesis; can modulate non-erythroid target tissues; and have been reported to affect the progression of certain cancers. Basic studies of EPOR expression and trafficking, however, have been hindered by low-level EPOR...

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Bibliographic Details
Main Authors: Seema Singh, Rakesh Verma, Anamika Pradeep, Karen Leu, R Bruce Mortensen, Peter R Young, Miho Oyasu, Peter J Schatz, Jennifer M Green, Don M Wojchowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3257245?pdf=render

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http://europepmc.org/articles/PMC3257245?pdf=render

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