In Vivo Differential Brain Clearance and Catabolism of Monomeric and Oligomeric Alzheimer’s Aβ protein

In Vivo Differential Brain Clearance and Catabolism of Monomeric and Oligomeric Alzheimer’s Aβ protein

Amyloid β (Aβ) is the major constituent of the brain deposits found in parenchymal plaques and cerebral blood vessels of patients with Alzheimer’s disease (AD). Several lines of investigation support the notion that synaptic pathology, one of the strongest correlates to cognitive impairment, is rela...

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Bibliographic Details
Main Authors: Farron Lynn McIntee, Patrizia Giannoni, Steven Blais, George Sommer, Thomas Neubert, Agueda Rostagno, Jorge Ghiso
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
Cerebrospinal Fluid
Aβ brain efflux
Aβ brain homeostasis
local proteolytic degradation
targeted mass spectrometric analysis
stereotaxic intracerebral injection
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00223/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00223/full

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