Increased Expression of NPM1 Suppresses p27<sup>Kip1</sup> Function in Cancer Cells

p27<sup>Kip1</sup>, a major cyclin-dependent kinase inhibitor, is frequently expressed at low levels in cancers, which correlates with their malignancy. However, in this study, we found a qualitative suppression of p27 overexpressed in some cancer cells. By proteomic screening for factor...

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Bibliographic Details
Main Authors: Tatsuya Kometani, Takuya Arai, Taku Chibazakura
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/12/10/2886