Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease

Alzheimer's Disease (AD) is associated with neuropathological changes, including aggregation of tau neurofibrillary tangles (NFTs) and amyloid-beta plaques. Mounting evidence indicates that vascular dysfunction also plays a key role in the pathogenesis and progression of AD, in part through end...

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Bibliographic Details
Main Authors: Annie G. Bryant, Miwei Hu, Becky C. Carlyle, Steven E. Arnold, Matthew P. Frosch, Sudeshna Das, Bradley T. Hyman, Rachel E. Bennett
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Neurology
Subjects:
Alzheimer's disease
tau pathology
neurofibrillary tangles
vascular dysfunction
endothelial senescence
gene expression
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.575953/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2020.575953/full

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