Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock.

Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock.

Excessive inflammatory and oxidative stress lead to circulatory failure, multiple organ dysfunction, and high mortality in patients with sepsis. Microbial infection-induced DNA hypermethylation is associated with the augmentation of inflammation and oxidative stress. In our previous study, the antia...

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Bibliographic Details
Main Authors: Chih-Chin Shih, Mei-Hui Liao, Tsan-Seng Hsiao, Hiong-Ping Hii, Ching-Hui Shen, Shiu-Jen Chen, Shuk-Man Ka, Yung-Lung Chang, Chin-Chen Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5035080?pdf=render

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http://europepmc.org/articles/PMC5035080?pdf=render

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