Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles

Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles

Neurodegenerative diseases are characterized by oxidative stress, mitochondrial damage, and death of neuronal cells. To counteract such damage and to favor neurogenesis, neurotrophic factors could be used as therapeutic agents. Octadecaneuropeptide (ODN), produced by astrocytes, is a potent neuropro...

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Bibliographic Details
Main Authors: Amira Namsi, Thomas Nury, Amira. S. Khan, Jérôme Leprince, David Vaudry, Claudio Caccia, Valerio Leoni, Atanas G. Atanasov, Marie-Christine Tonon, Olfa Masmoudi-Kouki, Gérard Lizard
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
octadecaneuropeptide (ODN)
N2a cells
neuronal differentiation
mitochondria
peroxisome
fatty acids
cholesterol
cholesterol precursors
Online Access:https://www.mdpi.com/1420-3049/24/18/3310

Internet

https://www.mdpi.com/1420-3049/24/18/3310

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