FOXO3 Selectively Amplifies Enhancer Activity to Establish Target Gene Regulation

FOXO3 Selectively Amplifies Enhancer Activity to Establish Target Gene Regulation

Forkhead box O (FOXO) transcription factors regulate diverse cellular processes, affecting tumorigenesis, metabolism, stem cell maintenance, and lifespan. We show that FOXO3 transcription regulation mainly proceeds through the most active subset of enhancers. In addition to the general distinction...

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Bibliographic Details
Main Authors: Astrid Eijkelenboom, Michal Mokry, Lydia M. Smits, Edward E. Nieuwenhuis, Boudewijn M.T. Burgering
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713006980

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http://www.sciencedirect.com/science/article/pii/S2211124713006980

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