Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat

Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat

Abstract Background Recently, depression has been identified as a prevalent and severe mental disorder. However, the mechanisms underlying the depression risk remain elusive. The neuroinflammation and NLRP3 inflammasome activation are known to be involved in the pathology of depression. Dihydrolipoi...

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Bibliographic Details
Main Authors: Hetao Bian, Gaohua Wang, Junjie Huang, Liang Liang, Yage Zheng, Yanyan Wei, Hui Wang, Ling Xiao, Huiling Wang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Neuroinflammation
Subjects:
Dihydrolipoic acid
Neuroinflammation
NLRP3
Lipopolysaccharide
Depression
Online Access:http://link.springer.com/article/10.1186/s12974-020-01836-y

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http://link.springer.com/article/10.1186/s12974-020-01836-y

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