Structural guided scaffold phage display libraries as a source of bio-therapeutics.

Structural guided scaffold phage display libraries as a source of bio-therapeutics.

We have developed a structurally-guided scaffold phage display strategy for identification of ligand mimetic bio-therapeutics. As a proof of concept we used the ligand of integrin αvβ6, a tumour cell surface receptor and a major new target for imaging and therapy of many types of solid cancer. NMR s...

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Bibliographic Details
Main Authors: Y K Stella Man, Danielle DiCara, Nicole Chan, Sandrine Vessillier, Stephen J Mather, Michelle L Rowe, Mark J Howard, John F Marshall, Ahuva Nissim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3739823?pdf=render

Internet

http://europepmc.org/articles/PMC3739823?pdf=render

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