Synchrotron-based infrared spectroscopy brings to light the structure of protein aggregates in neurodegenerative diseases

The accumulation of misfolded proteins in the form of aggregates characterizes a number of diseases of the central nervous system such as Alzheimer’s disease, Parkinson’s disease, prion diseases, and the diseases of polyglutamine expansion. Recent evidence obtained in vitro and in mice has suggested...

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Bibliographic Details
Main Authors: Hoffner Guylaine, André William, Sandt Christophe, Djian Philippe
Format: Article
Language:English
Published: De Gruyter 2014-12-01
Series:Reviews in Analytical Chemistry
Subjects:
Online Access:https://doi.org/10.1515/revac-2014-0016