Identification of a pituitary ERα-activated enhancer triggering the expression of Nr5a1, the earliest gonadotrope lineage-specific transcription factor

Identification of a pituitary ERα-activated enhancer triggering the expression of Nr5a1, the earliest gonadotrope lineage-specific transcription factor

Abstract Background Gonadotrope lineage differentiation is a stepwise process taking place during pituitary development. The early step of gonadotrope lineage specification is characterized by the expression of the Nr5a1 transcription factor, a crucial factor for gonadotrope cell fate determination....

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Bibliographic Details
Main Authors: Vincent Pacini, Florence Petit, Bruno Querat, Jean-Noël Laverriere, Joëlle Cohen-Tannoudji, David L’hôte
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Epigenetics & Chromatin
Subjects:
Gonadotrope specification
Enhancer
Epigenetic
Nr5a1
Estrogen receptor
Online Access:http://link.springer.com/article/10.1186/s13072-019-0291-8

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http://link.springer.com/article/10.1186/s13072-019-0291-8

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