Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium

Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous solubility. One of the ways to enhance the aqu...

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Bibliographic Details
Main Authors: Indumathi Sathisaran, Sameer Vishvanath Dalvi
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Pharmaceutics
Subjects:
crystal engineering
cocrystals
coformers
eutectics
polymorphism
poorly water-soluble
dissolution enhancement
hydrogen bonding
Online Access:http://www.mdpi.com/1999-4923/10/3/108

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http://www.mdpi.com/1999-4923/10/3/108

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