Global DNA hypermethylation in down syndrome placenta.

Global DNA hypermethylation in down syndrome placenta.

Down syndrome (DS), commonly caused by an extra copy of chromosome 21 (chr21), occurs in approximately one out of 700 live births. Precisely how an extra chr21 causes over 80 clinically defined phenotypes is not yet clear. Reduced representation bisulfite sequencing (RRBS) analysis at single base re...

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Bibliographic Details
Main Authors: Shengnan Jin, Yew Kok Lee, Yen Ching Lim, Zejun Zheng, Xueqin Michelle Lin, Desmond P Y Ng, Joanna D Holbrook, Hai Yang Law, Kenneth Y C Kwek, George S H Yeo, Chunming Ding
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3675012?pdf=render

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http://europepmc.org/articles/PMC3675012?pdf=render

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