Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats

<p>Abstract</p> <p>Background</p> <p>The development of analgesic tolerance following chronic morphine administration can be a significant clinical problem. Preclinical studies demonstrate that chronic morphine administration induces spinal gliosis and that inhibition o...

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Bibliographic Details
Main Authors: Milne Brian, Mattioli Theresa-Alexandra M, Cahill Catherine M
Format: Article
Language:English
Published: SAGE Publishing 2010-04-01
Series:Molecular Pain
Online Access:http://www.molecularpain.com/content/6/1/22