Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility.

Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility.

Aldosterone blockade confers substantial cardiovascular and renal protection. The effects of aldosterone on mineralocorticoid receptors (MR) expressed in endothelial cells (EC) within the renal vasculature have not been delineated. We hypothesized that lack of MR in EC may be protective in renal vas...

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Bibliographic Details
Main Authors: Sidsel B Laursen, Stine Finsen, Niels Marcussen, Susan E Quaggin, Pernille B L Hansen, Henrik Dimke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5821352?pdf=render

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http://europepmc.org/articles/PMC5821352?pdf=render

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