Mahuang Decoction Antagonizes Acute Liver Failure via Modulating Tricarboxylic Acid Cycle and Amino Acids Metabolism

Mahuang Decoction Antagonizes Acute Liver Failure via Modulating Tricarboxylic Acid Cycle and Amino Acids Metabolism

Acute liver failure (ALF) is a serious clinical disorder with high fatality rates. Mahuang decoction (MHD), a well-known traditional Chinese medicine, has multiple pharmacological effects, such as anti-inflammation, anti-allergy, anti-asthma, and anti-hyperglycemia. In this study, we investigated th...

Full description

Bibliographic Details
Main Authors:	Wenting Liao, Qiwen Jin, Junning Liu, Yiling Ruan, Xinran Li, Yueyue Shen, Zhicheng Zhang, Yong Wang, Shengming Wu, Junying Zhang, Lifeng Kang, Chunyong Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Pharmacology
Subjects:	mahuang decoction acute liver failure metabolomics UPLC-Q-exactive-MS tricarboxylic acid cycle amino acids metabolism
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.599180/full

Similar Items

The Study on Application of Mahuang-chuanwu Herbal Acupuncture(마황천오약침) to the treatment of obesity
by: Seok-woo Choi, et al.
Published: (2006-12-01)

Biochemical and Metabolic Implications of Tricarboxylic Acids and their Transporters
by: Khalifa El-Dawy, et al.
Published: (2019-06-01)

Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses
by: Inseok Choi, et al.
Published: (2021-01-01)

Application of Translational Medicine Theory in Chinese Materia Medica: Effect and Mechanism of Mahuang and Wuweizi on Pulmonary Fibrosis
by: Hai-zhi QIN, et al.
Published: (2015-06-01)

Application of citrate as a tricarboxylic acid (TCA) cycle intermediate, prevents diabetic-induced heart damages in mice
by: Qianqian Liang, et al.
Published: (2016-01-01)

The Role of Tricarboxylic Acid Cycle Metabolites in Viral Infections
by: Francisco Javier Sánchez-García, et al.
Published: (2021-09-01)

Disruption of the MreB Elongasome Is Overcome by Mutations in the Tricarboxylic Acid Cycle
by: Brody Barton, et al.
Published: (2021-04-01)

Edwardsiella tarda Tunes Tricarboxylic Acid Cycle to Evade Complement-Mediated Killing
by: Zhi-xue Cheng, et al.
Published: (2017-12-01)

A plant pathogenic bacterium exploits the tricarboxylic acid cycle metabolic pathway of its insect vector
by: Nabil Killiny, et al.
Published: (2018-12-01)

Implementation of a straightforward derivatizationmethod for the simultaneous analysis of short chainfatty acids and tricarboxylic acid cycle metabolitesby LC-qToF-MS.
by: Levisson, Renée
Published: (2021)

Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors
by: Miroslawa Cichorek, et al.
Published: (2020-10-01)

Pyruvate Dehydrogenase and Tricarboxylic Acid Cycle Enzymes Are Sensitive Targets of Traumatic Brain Injury Induced Metabolic Derangement
by: Giacomo Lazzarino, et al.
Published: (2019-11-01)

The Role of Iodine Catalyst in the Synthesis of 22-Carbon Tricarboxylic Acid and Its Ester: A Case Study
by: Yanxia Liu, et al.
Published: (2019-11-01)

BasS/BasR Two-Component System Affects the Sensitivity of Escherichia coli to Plantaricin BM-1 by Regulating the Tricarboxylic Acid Cycle
by: Chen, X., et al.
Published: (2022)

Growth Enhancement Facilitated by Gaseous CO<sub>2</sub> through Heterologous Expression of Reductive Tricarboxylic Acid Cycle Genes in <i>Escherichia coli</i>
by: Shou-Chen Lo, et al.
Published: (2021-06-01)

Regulatory interactions of enzymes of the citric acid cycle in Bacillus subtilis
by: Meyer, Frederik
Published: (2013)

Simultaneous Measurement of Tricarboxylic Acid Cycle Intermediates in Different Biological Matrices Using Liquid Chromatography–Tandem Mass Spectrometry; Quantitation and Comparison of TCA Cycle Intermediates in Human Serum, Plasma, Kasumi-1 Cell and Murine Liver Tissue
by: Ramji Rathod, et al.
Published: (2020-03-01)

Organic Acids: The Pools of Fixed Carbon Involved in Redox Regulation and Energy Balance in Higher Plants
by: Abir U Igamberdiev, et al.
Published: (2016-07-01)

Rational modification of tricarboxylic acid cycle for improving l-lysine production in Corynebacterium glutamicum
by: Jian-Zhong Xu, et al.
Published: (2018-07-01)

Impact of Ohmic-Assisted Decoction on Bioactive Components Extracted from Yacon (Smallanthus sonchifolius Poepp.) Leaves: Comparison with Conventional Decoction
by: Forough Khajehei, et al.
Published: (2017-11-01)

Effects of different principles of Traditional Chinese Medicine treatment on TLR7/NF-κB signaling pathway in influenza virus infected mice
by: Ying-Jie Fu, et al.
Published: (2018-08-01)

A 42-Markers Pharmacokinetic Study Reveals Interactions of Berberine and Glycyrrhizic Acid in the Anti-diabetic Chinese Medicine Formula Gegen-Qinlian Decoction
by: Xue Qiao, et al.
Published: (2018-06-01)

Connections Between Amino Acid Metabolisms in Plants: Lysine as an Example
by: Qingqing Yang, et al.
Published: (2020-06-01)

Crystal structure of [NaZn(BTC)(H2O)4]·1.5H2O (BTC = benzene-1,3,5-tricarboxylate): a heterometallic coordination compound
by: Min Ni, et al.
Published: (2015-07-01)

Amino Acid and Carbohydrate Metabolism Are Coordinated to Maintain Energetic Balance during Drought in Sugarcane
by: Augusto Lima Diniz, et al.
Published: (2020-11-01)

Gegen Qinlian Decoction Treats Diarrhea in Piglets by Modulating Gut Microbiota and Short-Chain Fatty Acids
by: Chang-Shun Liu, et al.
Published: (2019-04-01)

Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases
by: Cerena Moreno, et al.
Published: (2020-11-01)

Prediction of Autoimmune Diseases by Targeted Metabolomic Assay of Urinary Organic Acids
by: Dimitris Tsoukalas, et al.
Published: (2020-12-01)

Branched-Chain Amino Acid Levels Are Related with Surrogates of Disturbed Lipid Metabolism among Older Men
by: Urho M Kujala, et al.
Published: (2016-11-01)

2,3,6-Tricarboxylate Cellulose as a Fully Biodegradable Flocculant: Efficient Synthesis and Flocculation Performance
by: Kexin Chen, et al.
Published: (2016-05-01)

Cutaneous lipogenesis: precursors utilized by guinea pig skin for lipid synthesis
by: VICTOR R. WHEATLEY, et al.
Published: (1971-05-01)

The Interaction of Hydrogen with Iron Benzene-1,3,5-Tricarboxylate (Fe-BTC)
by: Stewart F. Parker
Published: (2020-10-01)

Aliphatic medium chain tricarboxylic acids in rat urine
by: B Eliasson, et al.
Published: (1976-11-01)

Analysis of organic acids of tricarboxylic acid cycle in plants using GC-MS, and system modeling
by: Vinod Kumar, et al.
Published: (2017-10-01)

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver[S]
by: Santhosh Satapati, et al.
Published: (2012-06-01)

Crystal structure of 5-[(4-carboxybenzyl)oxy]isophthalic acid
by: Md. Serajul Haque Faizi, et al.
Published: (2016-08-01)

Antibiotic Treatment in <i>Anopheles coluzzii</i> Affects Carbon and Nitrogen Metabolism
by: Estelle Chabanol, et al.
Published: (2020-08-01)

Fumarase From Cyanidioschyzon merolae Stably Shows High Catalytic Activity for Fumarate Hydration Under High Temperature Conditions
by: Shoki Ito, et al.
Published: (2020-09-01)

Seasonal variations in photoperiod affect hepatic metabolism of medaka (Oryzias latipes)
by: Koichi Fujisawa, et al.
Published: (2021-04-01)

Changes in Alternative Splicing in Apis Mellifera Bees Fed Apis Cerana Royal Jelly
by: Shi Yuan Yuan, et al.
Published: (2014-12-01)